Scientist, RNA Biochemistry Job at Cloverleaf Bio, New Haven, CT

ZlpTRnQ0RFhlbForS0I0U253WWJzNVdPUkE9PQ==
  • Cloverleaf Bio
  • New Haven, CT

Job Description

About Us

Cloverleaf Bio is an early-stage therapeutics company that is developing a new class of engineered tRNA therapeutics. Our tRNAs target an underappreciated vulnerability of cancer: addiction to high levels of tRNA modifying enzymes. Cloverleaf's approach to drugging tRNA modifying enzymes uses engineered “trojan horse” tRNAs to modulate translation in cancerous cells. The programmability, potency, and specificity of our tRNAs gives us the potential to dramatically improve cancer treatment.

The Job

We are seeking an experienced RNA Biochemist to join our team. In this position, you will work in close conjunction with our founding team in the creation and development of a completely novel family of RNA therapeutics.

Your responsibilities will range from designing and performing both low and high-throughput RNA screening assays, generation of RNA sequencing libraries, performing mechanistic studies in cells on lead candidate RNAs, and diving into new disease areas beyond oncology.

About You

Excited by the science. We are excited by how science can improve the world and are looking for people who are too.

Flexible. We wear many different hats and are looking for people who are willing to do whatever it takes to pitch in and get the job done.

Resilient. Working in an early-stage startup can be hard. Science is hard. We are looking for people who have a demonstrated track record of sticking with complex problems for the long haul.

Cooperative. As a small team, communication and collaboration are key. We are looking for people who thrive working both independently and collaboratively.

Qualifications:

  • PhD in Biochemistry, Molecular Biology, Genetics or related fields.
  • Strong problem solving skills.
  • Demonstrated ability to independently drive research projects to completion in academic or industrial settings.
  • Experience with standard molecular biology techniques, including but not limited to, RNA/DNA extraction, PCR, RT-PCR, qPCR, western blotting, etc.
  • Skilled in mammalian cell culture, passaging/seeding cells, etc.

Nice to haves:

  • Competency generating libraries for RNA sequencing (such as mRNA-seq, CLIP-seq, etc.).
  • Comfortable at analyzing NGS data analysis using conventional bioinformatics tools.
  • Research experience in tRNA, RNA biology and/or RNA modifications field.
  • Experience with design/development RNA therapeutics and lipid nanoparticles.
  • Experience with mouse models of oncology.

Benefits

  • Competitive salary commensurate with experience and strong equity incentives.
  • Medical, dental, and vision coverage.
  • Brand new lab space in BioLabs New Haven in downtown New Haven, close to the Yale Shuttle, I-95/91 and Metro North.
  • We will provide a stimulating, collegial, and fast-paced environment. If you are interested in joining our team, then we are excited to hear from you! Please submit resumes at cloverleafbio.com (

Job Tags

Full time, Flexible hours,

Similar Jobs

Specialized Dental Partners

Dental Hygienist Partime Job at Specialized Dental Partners

 ...Title :: Dental Hygienist Office :: Millennium Periodontics Location :: 223 W Jackson Blvd, Suite 1275, Chicago, Illinois, US, 60606 Position Type :: Part Time Schedule : Tuesdays, Thursdays, and every other Friday We are seeking a compassionate and... 

HAYES CENTER PUBLIC SCHOOLS

High School Secretary Job at HAYES CENTER PUBLIC SCHOOLS

 ...Hayes Center Public Schools has a High School Secretary position open for the 2026-27 school year. Skills needed to be successful include excellent communication skills, ability to operate office equipment, including computer, scanner and copier. The secretary will also... 

HomeStar Remodeling

Residential Exterior Project Manager Job at HomeStar Remodeling

 ...Project Manager - High-Growth Leadership Opportunity About HomeStar HomeStar is a premier, fast-growing remodeling company offering...  ..., specifications, and company expectations Perform accurate material take-offs and ensure proper ordering Clearly communicate... 

Plants and Goodwin, Inc.

Diesel / Heavy Equipment Mechanic Job at Plants and Goodwin, Inc.

 ...Job Description ~ Full-Time Diesel / Heavy EquipmentMechanic: ~$23.00 - $35.00 per hour starting wages depending upon experience...  ..., air conditioning, fuel, emission, brake, steering, hydraulics; completes machine shop operations; making adjustments and alignments... 

Panda Restaurant Group

Assistant Manager Job at Panda Restaurant Group

 ...Express is searching for experienced leaders to join our store management team. Panda is 100% committed to the professional and personal...  ...that cares about your success. What You'll Do As An Assistant Manager: You are in charge of assisting the operation of a...